The Scientist

All About Alternative Splicing

This article was review by Thomas Cooper, MD from Baylor College of Medicine. Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global ...
Phys.org

Cells use alternative splicing to regulate gene expression, research suggests

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...
Medical Xpress

Alternative RNA splicing tied to schizophrenia-like behaviors in animal models

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A gene in schizophrenia. The research was conducted by scientists led by LI Ming ...
Nature

Does species-specific alternative splicing make us human?

The 2012 article published in Science by Blencowe and colleagues (with a back-to-back article from the Burge lab) is the paper I have spent the most time thinking about. I find it inspiring in many ...
Medical Xpress

Study uncovers new insights into alternative splicing and disease associations

Alternative splicing, a process where a single gene can give rise to multiple different proteins via inclusion or exclusion of certain segments of the gene sequence, is known to occur in over 90% of ...
GEN

Alternative Splicing’s Unproductive Transcripts Eliminated by Nonsense-Mediated Decay

Alternative splicing (AS) is a genetic process that increases the diversity of proteins that can be generated from genes, by assembling sections of genetic code into different combinations. This is ...
Science Daily

Cell-type-specific link between alternative splicing and autoimmune disease inheritance discovered

Computational biologists have uncovered how RNA splicing -- a crucial process for isoform expression and protein diversity -- is regulated across different cell types in the peripheral blood. This ...
Science Daily

Deregulation of alternative RNA splicing promotes pancreatic cancer progression and metastasis

In a new study, researchers demonstrate that deregulation of a protein called RBFOX2, involved in RNA splicing, contributes to the progression and metastasis of pancreatic cancer. Pancreatic cancer ...
News Medical

Long-read RNA sequencing reveals novel insights into alternative splicing and disease genetics

Tokyo Medical and Dental University (TMDU) researchers harness long-read RNA sequencing to decode genetic intricacies and disease links. Alternative splicing, a process where a single gene can give ...
ascopubs.org

Multiple alternative splicing of HER2 transcripts and exon skipping with potential consequences on function and antibody-based therapy.

Trastuzumab deruxtecan in patients with breast cancer with brain metastases: The DE-REAL study. Safety and efficacy of trastuzumab deruxtecan for metastatic HER2+ and HER2-low breast cancer: An ...
EurekAlert!

Researchers highlight role of alternative RNA splicing in schizophrenia

In an important new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A gene in schizophrenia. The research was conducted by scientists led ...