Neutrophils make up approximately 70% of the white blood cells in humans and serve as a first line of defense against invading pathogens. Two mechanisms of action, the release of cytotoxic molecules ...

The complement system was described over 100 years ago, and it is well established that activation of this pathway accompanies the great majority of autoimmune and inflammatory diseases. In addition, ...

Immunotherapy is increasingly becoming standard therapy in cancer, with technology, such as checkpoint inhibitors and cell therapy, raising the efficacy bar in many forms of the disease. But the ...

Anti-HLA antibodies hamper successful transplantation, and activation of the complement cascade is involved in antibody-mediated rejection. We investigated whether the complement-binding capacity of ...

Managing complement 3 glomerulopathy involves several treatment options aimed at slowing disease progression and protecting kidney function. These may include blood pressure control, steroids, ...

A complement blood test measures how well complement proteins in your blood support immune defense. The complement system helps antibodies fight germs and clear foreign substances. Complement testing ...