The ability of natural selection to optimize traits depends on the topology of the genotype-fitness map (fitness landscape). Epistatic interactions produce rugged fitness landscapes, where adaptation ...

Overall, another way to think about complementation is the concept of ‘interoperable regions’, derived from ‘semantic interoperability’ in computer science, which refers to the ability of computers to ...

For decades, scientists have theorized that two genetic defects have the potential to essentially “cancel each other out,” restoring normal protein function in the process. A new study confirms this ...