The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

Cryo-EM reconstructions of the human ATR–ATRIP complex show how clinical small-molecule inhibitors like VE-822 and RP-3500 bind to and inhibit ATR activity. A research team led by Prof. Gang Cai and ...

DNA aptamers are powerful molecular tools in biosensing, bioimaging and therapeutics. However, a limited understanding of their tertiary structures and binding mechanisms hinders their further ...

Chemerin is a key adipokine that regulates lipid metabolism and insulin sensitivity, and thus is involved in many metabolic diseases such as obesity and diabetes. In addition, it plays a critical role ...

Proteins are the molecular workhorses of cells. To understand their functions, scientists soon realized that they had to figure out proteins’ shapes. But solving a protein structure is a challenging ...

The rapid advancements in satellite technology have been inextricably bound up with the support provided by sophisticated space folding mechanisms. In addition, with the rapid progression of space ...

Biological motors, which aid microorganism movement in fluids, are composed of two components -- the rotor and stators. Despite much research, the exact molecular mechanism underlying stator function ...

With the growing demand for resilient, efficient, and low carbon infrastructure, increasing attention has been directed toward novel materials and ...