Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

The Polymerase Chain Reaction (PCR) is a technique for the amplification of DNA in vitro (this describes experiments with cells outside their normal environment). PCR amplifies DNA using complementary ...

Together, these results reinforce the notion that PCNA and lagging-strand processes undergo functional exhaustion during unperturbed origin activation and become further depleted upon unscheduled ...

DNA replication stress responses are guardians of genomic stability critical during development, hematopoiesis, cancer therapy response, aging and disease suppression. Central to these responses are ...