Nature

Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype

Conventional laboratory mice housed under specific pathogen-free (SPF) conditions are the standard model in biomedical research. However, in recent years, many rodent-based studies have been deemed ...
Nature

Timing of standard chow exposure determines the variability of mouse phenotypic outcomes and gut microbiota profile

Standard chow diets influence reproducibility in animal model experiments because chows have different nutrient compositions, which can independently influence phenotypes. However, there is little ...
Medical Xpress

Mouse models for ultra-rare disorder could pave the way for nervous system gene editing therapies

Scientists at The Jackson Laboratory (JAX) have developed mouse models that survive premature death and enable pre-clinical testing of alternating hemiplegia of childhood (AHC), a devastating and ...
Science Daily

CAST mouse model: A crucial tool for future COVID-19 outbreaks

Researchers have identified the first mouse strain that is susceptible to severe COVID-19 without the need for genetic modification. This development marks a pivotal step forward in infectious disease ...
STAT

Modern animal models for biomedical research remain far better than alternatives

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...