Everyone who ever took a photo knows the problem: if you want a detailed image, you need a lot of light. In microscopy, however, too much light is often harmful to the sample—for example, when imaging ...

Cell culture techniques have evolved well beyond early simplistic 2D monolayers to mimic nearly all features of a complex in vivo tissue environment. These new advanced models seek to replicate fully ...

The resolution and contrast of microscope imaging is often affected by aberrations introduced by imperfect optical systems and inhomogeneous refractive structures in specimens. Adaptive optics (AO) ...

Introduction to SNOM: The Scanning Near-field Optical Microscope (SNOM) stands as a pivotal analytical tool in nanotechnology, enabling the visualization of nanostructures with resolution beyond the ...

Materials scientists can learn a lot about a sample material by shooting lasers at it. With nonlinear optical microscopy—a specialized imaging technique that looks for a change in the color of intense ...

Deep inside a small, windowless room at the University of California, Berkeley, two microscopes are quietly capturing some of ...