Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...

Fifteen years ago, physicists worked out a method to increase image contrast by hitting the electron imaging beam with an ...

A new microscope method reveals details that were difficult to see before, helping researchers study proteins, cells, and ...

In a landmark achievement in biological imaging, researchers at the University of California, Berkeley and Biohub today ...

Installed in a custom Titan Krios, the laser phase plate enhances motion correction, early‑frame recovery, and 3D classification and alignment.

In a landmark achievement in biological imaging, researchers at Biohub and the University of California, Berkeley today announced the successful demonstration of the laser phase plate, a novel device ...

The invention that first enabled researchers to see clear images of living cells was the phase-contrast microscope, which won its inventor, Frits Zernike, a Nobel Prize in 1932. Prior to Zernike's ...

Light microscopy is a key tool that scientists use to image cells, organelles, subcellular structures, and molecules such as proteins and nucleic acids. Because visible light leaves biological ...

Biologists are very interested in how proteins, lipids and other compounds are organized and interact in systems. Very few organizational details can be gained by using standard transmission-based ...