Medscape

Etravirine: A Novel Nonnucleoside Reverse Transcriptase Inhibitor for Managing Human Immunodeficiency Virus Infection

Purpose: The pharmacology, efficacy, and safety of etravirine and its clinical utility with respect to the available alternative human immunodeficiency virus (HIV) treatment options are reviewed.
ascopubs.org

Reverse transcriptase inhibitors reduce tumor growth in vivo and induce cell differentiation

Potentiation of apoptosis inducing activity of BL-193, an inhibitor of Bcl-XL protein, by genistein in pancreatic cancer cells No significant financial relationships to disclose. This is an ASCO ...
Business Wire

ROME Therapeutics Presents First Data to Validate LINE-1 RT as a Novel Target in Autoimmune Diseases and the Therapeutic Potential of its First-in-Class LINE-1 RT Inhibitors

BOSTON--(BUSINESS WIRE)--ROME Therapeutics, a biotechnology company harnessing the power of the dark genome to develop breakthrough medicines for serious diseases, announced new data validating the ...
BioWorld

Rome Therapeutics divulges new L1RE1 and HERV-K reverse transcriptase inhibitors

Rome Therapeutics Inc. has synthesized 4’-halomethyl-cytidine phosphoramidate compounds acting as LINE-1 retrotransposable element ORF1 protein (L1RE1) and/or HERV-K reverse transcriptase inhibitors ...
Infectious Disease Advisor

Dolutegravir Improves Long-Term HIV Outcomes in Children and Adolescents

Among pediatric patients with HIV, DTG-based ART showed superior efficacy compared with standard care regimens over 240 weeks.
Nature

Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells

A strategy to functionally cure AIDS by eliminating latent HIV-1 reservoirs involves non-nucleoside reverse transcriptase inhibitors (NNRTIs) that promote pyroptosis of HIV-1 infected cells. These ...
Medscape

Certain HIV Meds Linked to Reduced Alzheimer’s Risk

Use of nucleoside reverse transcriptase inhibitors (NRTIs), but not other medications for HIV, was associated with a significantly reduced risk for Alzheimer’s disease (AD) in an analysis of two ...
The Scientist

Thermostable Reverse Transcriptase at Room Temperature

New England Biolabs (NEB®) announced today that they have released a novel, thermostable reverse transcriptase, WarmStart® RTx Reverse Transcriptase, specifically designed for nucleic acid detection.
Science Daily

Common HIV treatments may aid Alzheimer's disease patients

Scientists have identified promising real-world links between common HIV drugs and a reduced incidence of Alzheimer's disease. Alzheimer's disease (AD) currently afflicts nearly seven million people ...
News Medical

Reverse transcriptase activity found in aging and Alzheimer’s brains

Alzheimer's disease is the most common cause of dementia and affects more than a tenth of Americans aged 65 and older. The disease has proven difficult to develop new treatments for, and available ...
BioWorld

Rome Therapeutics presents new inhibitors of LINE1 or HERV-K reverse transcriptase

Rome Therapeutics Inc. has divulged didehydro-3’-deoxy-4’-ethynylthymidines acting as LINE-1 retrotransposable element ORF1 protein (L1RE1) and/or HERV-K reverse transcriptase inhibitors reported to ...