Physicists introduce phase contrast to electron microscopy, delivering sharper images of our body's tiniest proteins

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...
Nature

Improved image contrast in nonlinear light-sheet fluorescence microscopy using i\(^2\)PIE Pulse compression

Light-sheet fluorescence microscopy (LSFM) has allowed for faster three-dimensional imaging of biological samples with lower photo-bleaching and photo-toxicity than confocal microscopy 1. This is ...
C&EN

A new, ultrabright laser powers a cryo-EM advance 15 years in the making

Fifteen years ago, physicists worked out a method to increase image contrast by hitting the electron imaging beam with an ...
The Scientist

Improvements In Light Microscopy Lead To New Applications

The invention that first enabled researchers to see clear images of living cells was the phase-contrast microscope, which won its inventor, Frits Zernike, a Nobel Prize in 1932. Prior to Zernike's ...
Nature

Machine learning approach for recognition and morphological analysis of isolated astrocytes in phase contrast microscopy

Astrocytes are glycolytically active cells in the central nervous system playing a crucial role in various brain processes from homeostasis to neurotransmission. Astrocytes possess a complex branched ...