A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...
We have developed a highly sensitive polymerase chain reaction (PCR)-based technique termed two-step PCR, which uses arbitrary primers to identify proviral integration sites in retrovirally marked ...
No integration site accounted for more than 30% of the total integration events on two consecutive tests. The vector copy number in peripheral blood ranged from 0.10 to 1.55 at month 24 (assessed in ...
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