Every time a cell copies its DNA, parts of the genome are exposed and vulnerable to damage or errors. Molecular biologist ...

WEE1 functions as a checkpoint gatekeeper; inhibition forces cell-cycle progression despite unrepaired DNA damage, leveraging tumor replication stress and p53/repair deficits to induce mitotic ...

Researchers at Oregon Health & Science University have identified a previously unrecognised role for the cancer-associated ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

A protein best known for driving cancer growth also helps damaged tumor cells survive by repairing their DNA, according to a new study that could influence how some cancers are treated. Researchers at ...

Rosalie Sears, Ph.D., is senior author of a new study published in Genes & Development. Her team at OHSU found that the cancer-driving protein MYC also helps damaged tumor cells survive treatment by ...

U.S. Department of Agriculture activity starting Thursday night at Indiana University’s Myers Hall left biology labs shut down and continued a chilling effect felt by researchers. It’s become more and ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered ...

Over a billion years ago, a single-celled archaean engulfed an overachieving bacterium. The bacterium didn’t perish but instead struck an agreement with its host. For shelter, the bacterium would pay ...

RIVERSIDE, Calif. -- Scientists at the University of California, Riverside, have discovered how adult stem cells retain their regenerative power. The researchers demonstrate in a paper published in ...